Actively Recruiting
Led by University of Zurich · Updated on 2025-01-16
85
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating the potential rapid antisuicidal effects of nitrous oxide (N2O) in treating suicidal thoughts across different diagnoses. This Phase 2 study involves adults aged 18 to 65 with moderate to severe suicidal ideation. The trial aims to understand how N2O impacts suicidal ideation and to explore biological mechanisms using hair and blood samples, along with EEG recordings. Participants will receive inhalation treatments on two separate days. On day 1, they will receive either 50% nitrous oxide combined with 50% oxygen or a placebo of 50% oxygen plus 50% air for 45 minutes. This first inhalation is double-blind, meaning neither participants nor raters know the treatment assigned. Seven days later, all participants will receive nitrous oxide during the second inhalation, with only the patients blinded. A nested biomarker substudy will collect hair, blood, and EEG data to study mechanisms and prediction. During the trial, participants will undergo assessments including the Beck Scale for Suicidal Ideation (BSS) measured from day 0 to day 2, along with other scales like the Montgomery-Åsberg Depression Rating Scale and suicide-related visual analog scales. EEG changes linked to inhalation treatments will be recorded on day 1. Researchers will monitor safety and responses closely throughout. Total participation involves inhalation sessions, clinical ratings, and biological sample collections from the start through day 8.
CONDITIONS
Nitrous Oxide in the Treatment of Acute Suicidal Ideation
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single treatment session
Participants receive inhalation treatment with either 50% nitrous oxide plus 50% oxygen or 50% oxygen plus air for 45 minutes while blinded to the treatment assignment.
1 treatment visit (in-person)
Total: 1 location
1
Psychiatric University Hospital Zurich
Zurich, Switzerland, 8032
Actively Recruiting
A
Angelina Frasch
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Golo Kronenberg, Anna Bankwitz, Barbora Provaznikova...
https://pubmed.ncbi.nlm.nih.gov/40669910