Actively Recruiting
NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP
Led by Northwell Health · Updated on 2023-10-31
100
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to compare two different modes of noninvasive ventilation in hypercapnic respiratory failure. The investigators will compare AVAPS and BIPAP S/T and hypothesize that AVAPS will result in a decreased length of stay in the ICU or on telemetry. Currently, noninvasive ventilation is the standard of care for hypercapnic respiratory failure. However, the most effective mode for patients with hypercapnic respiratory failure is unclear.
CONDITIONS
Official Title
NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent by patient or legal representative
- Willingness to comply with all study procedures and availability for the study duration
- Male or female aged 18 years or older
- Diagnosis of hypercapnic respiratory failure on admission confirmed by arterial blood gas
- Admitted to Lenox Hill Hospital medical ICU or telemetry unit
- Requiring noninvasive ventilation as determined by treating physician for hypercapnic respiratory failure
You will not qualify if you...
- Requirement for ventilation at predetermined tidal volumes
- Need for rapid and frequent IPAP adjustments to maintain consistent tidal volume
- Age less than 18 years
- Currently intubated
- Presence of chronic tracheostomy
- Pregnancy
- Hypotension
- Epistaxis (nosebleed)
- Untreated pertussis
- Acute sinusitis or otitis media
- Risk of aspiration of gastric contents
- Lack of spontaneous respiratory drive
- Inability to maintain a patent airway or clear secretions adequately
- Prisoners or other institutionalized individuals
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Lenox Hill Hospital
New York, New York, United States, 10075
Actively Recruiting
Research Team
S
Sara Velichkovikj
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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