Actively Recruiting
NMDA Modulation in Major Depressive Disorder
Led by China Medical University Hospital · Updated on 2025-02-19
90
Participants Needed
1
Research Sites
495 weeks
Total Duration
On this page
Sponsors
C
China Medical University Hospital
Lead Sponsor
M
Ministry of Science and Technology, Taiwan
Collaborating Sponsor
AI-Summary
What this Trial Is About
Most of the current antidepressants for major depressive disorder (MDD) are based upon the monoamine hypothesis which cannot fully explain the etiology of depression. NMDA hypofunction has been implicated in the pathophysiology of depression. Therefore, this study will examine the efficacy and safety as well as cognitive function improvement of an NMDA enhancer (NMDAE) in the treatment of MDD in the adults.
CONDITIONS
Official Title
NMDA Modulation in Major Depressive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a DSM-5 diagnosis of major depressive disorder (MDD)
- Have a 17-item Hamilton Rating Scale for Depression total score of 18 or higher
- Be free of antidepressant drugs for at least 2 weeks before the study
- Agree to participate in the study and provide informed consent
- Be between 18 and 55 years old
You will not qualify if you...
- Current substance abuse or history of substance dependence in the past 6 months
- History of epilepsy, head trauma, stroke, or other serious medical or neurological illness that may interfere with the study
- Diagnosis of bipolar depression, schizophrenia, or other psychotic disorders
- Moderate to severe suicidal risk
- Severe cognitive impairment
- Starting or stopping formal psychotherapy within 6 weeks prior to enrollment
- History of severe adverse reactions to SSRIs
- History of treatment resistance, defined as failure to respond to two or more different classes of antidepressants
- History of receiving electroconvulsive therapy
- Inability to follow the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Psychiatry, China Medical University Hospital
Taichung, Taiwan
Actively Recruiting
Research Team
H
Hsien-Yuan Lane, M.D., Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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