Actively Recruiting
No Reduction Compared to Closed Reduction for Distal Radius Fractures in Patients Over 65 or Older
Led by Tampere University Hospital · Updated on 2026-01-21
532
Participants Needed
10
Research Sites
413 weeks
Total Duration
On this page
Sponsors
T
Tampere University Hospital
Lead Sponsor
K
Kuopio University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
DISCLOSE trial is a randomized controlled trial including 532 participants with low-energy distal radius fractures. The primary objective is to evaluate whether casting without prior closed reduction is equivalent to casting following closed reduction with respect to wrist-related pain and disability, as measured by the Patient-Rated Wrist Evaluation (PRWE) score at 12 months, in patients aged 65 years or older with a displaced distal radius fracture. * Primary endpoint will be PRWE at 12 months * Follow-up visits are scheduled at 3 and 12 months. 5-year follow-up will be considered as an exploratory endpoint
CONDITIONS
Official Title
No Reduction Compared to Closed Reduction for Distal Radius Fractures in Patients Over 65 or Older
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older
- Independent living patients
- Displaced distal radius fracture (AO/OTA 23A/23C) with 15-40 degree dorsal angulation and/or shortening of the radius more than 2 mm
- Associated ulnar styloid fracture is allowed
- Low energy injury from a fall less than 1 meter
You will not qualify if you...
- Unable to provide consent
- Actively working in a paid position
- Volar angulation or partial articular fractures (AO/OTA 23B)
- Fracture of the ulna proximal to the base of the styloid process
- Other fractures or dislocations affecting use of the injured wrist
- Fractures in both arms
- Open injury Gustilo grade 2 or higher
- No bony contact between main fragments
- High energy injuries
AI-Screening
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Trial Site Locations
Total: 10 locations
1
Viborg regional Hospital
Viborg, Denmark
Actively Recruiting
2
Tartu University Hospital
Tartu, Estonia
Actively Recruiting
3
Tampere University Hospital
Tampere, Pirkanmaa, Finland, 33520
Actively Recruiting
4
Helsinki University Hospital
Helsinki, Uusimaa, Finland, 00260
Actively Recruiting
5
Kanta-Häme Central Hospital
Hämeenlinna, Finland
Actively Recruiting
6
Kuopio University Hospital
Kuopio, Finland
Actively Recruiting
7
Oulu University Hospital
Oulu, Finland, 90220
Actively Recruiting
8
Pori Central Hospital
Pori, Finland
Not Yet Recruiting
9
Turku University Hospital
Turku, Finland
Not Yet Recruiting
10
Karolinska University Hospital
Stockholm, Sweden
Not Yet Recruiting
Research Team
L
Laura Kärnä, MD
CONTACT
V
Ville Ponkilainen, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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