Study Comparing No Sedation and Daily Sedation Breaks in Adults with Chronic Obstructive Pulmonary Disease on Mechanical Ventilation

What this Trial Is About

Researchers are comparing two approaches to sedation in patients with Chronic Obstructive Pulmonary Disease COPD who need mechanical ventilation. The study evaluates no sedation versus daily interruption of sedation DIS to see which results in more ventilator-free days. This prospective study aims to improve care for COPD patients requiring ventilator support. One group of patients will be managed with a no sedation protocol, where agitation is addressed by identifying discomfort causes and managing them without physical restraints or sedation unless necessary. If agitation persists, a small dose of midazolam may be given, and if sedation is needed repeatedly, the patient will switch to the DIS protocol. The DIS group will have sedation managed daily with monitoring using the Richmond agitation and sedation score RASS. Participants will be closely monitored from day 1 to day 28 for ventilator-free days. Researchers will observe sedation levels, agitation, and patient comfort. The study will follow patients throughout their ICU stay to assess outcomes related to sedation management, with no crossover between groups except as described. The total participation duration corresponds to the ventilation period and monitoring up to 28 days.

No Sedation Versus Daily Interruption of Sedation in Chronic Obstructive Pulmonary Disease Mechanically Ventilated Patients- A Prospective Study