Actively Recruiting
NOAC Therapy Guided by PARIS Risk Score and D-dimer in Patients With ACS After PCI
Led by China National Center for Cardiovascular Diseases · Updated on 2024-01-17
3944
Participants Needed
1
Research Sites
161 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to compare short-term Triple Antithrombotic Therapy (DAPT + Rivaroxaban) followed by DAPT with standard DAPT in selected ACS patients with high ischemic risk. The main questions it aims to answer are: * Whether the intervention is effective in reducing ischemic events * Whether the intervention is safe from increasing bleeding events, especially severe or fatal ones Participants will be randomized to receive standard DAPT therapy for the entire study duration or low-dose rivaroxaban+DAPT for 3 months, followed by standard DAPT for the rest of the study duration. Patients enrolled should complete 5 follow-ups in the form of clinic visit or telephone call.
CONDITIONS
Official Title
NOAC Therapy Guided by PARIS Risk Score and D-dimer in Patients With ACS After PCI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Acute Coronary Syndrome 1-7 days after symptom stabilization
- Aged 18-65 years old
- Elevated D-dimer levels (≥0.28 µg/ml) or PARIS coronary thrombosis risk score ≥3 points
- Received Percutaneous Coronary Intervention and not on non-oral anticoagulants
- Indicated for dual antiplatelet medication
You will not qualify if you...
- Platelet level below 90 x10^6
- Hemoglobin level less than 11 g/dL
- History of severe bleeding
- History of stroke or transient ischemic attack (TIA)
- Severe liver or kidney failure
- Indicated for anticoagulation therapy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Chinese Academy of Medical Sciences, Fuwai Hospital
Beijing, Beijing Municipality, China, 100037
Actively Recruiting
Research Team
J
Jinqing Yuan, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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