Study of 1470 nm Non-Ablative Laser Treatment for Scarring Alopecia with Hair Follicle Gene Analysis

What this Trial Is About

Researchers are evaluating the use of a non-ablative 1470 nm laser to treat scarring alopecia in adults. This study aims to determine if the laser effectively treats scarring alopecia and to understand the molecular pathways affected by the laser in hair follicles. The trial includes participants with biopsy-proven or clinically diagnosed scarring alopecia who have not had recent hair loss treatments. Participants will receive three laser treatments spaced one month apart using the non-ablative Sciton HALO laser. Each session lasts about 10 to 15 minutes and involves applying a topical anesthetic and cleaning the scalp before treatment. The laser creates controlled micro-channels in the skin to minimize tissue damage while potentially improving treatment effects. After treatment, participants will follow standard care guidelines. During the study, hair follicle samples will be collected by plucking hairs before the first treatment and one month after the last treatment to analyze gene expression related to inflammation and fibrosis. Participants will attend five follow-up visits over 15 months for clinical assessments, including hair density measurement with a specialized device and photographic evaluations. They will also complete questionnaires, self-assessments, and keep a diary of any side effects. The main outcomes measured include hair density, hair counts, and aesthetic improvement scales over time.

Non-Ablative Laser to Treat Scarring Alopecia With Hair Follicle Gene Expression Analysis