Studying Benefits of Reduced Methamphetamine Use in Adults with Methamphetamine Use Disorder A 12-Week Treatment and Follow-up Trial of Behavioral Contingency Management

What this Trial Is About

Researchers are studying methamphetamine use disorder to evaluate the benefits of reducing drug use rather than complete abstinence. This research aims to fill a critical gap by showing how lowering methamphetamine use can improve physical, psychological, and social health. The findings may help change current treatment goals and speed up the development of new therapies for methamphetamine use disorder. Participants are randomly assigned to one of two groups. One group receives payments for providing urine samples, while the other group receives payments specifically for methamphetamine-negative urine samples as part of a behavioral approach called Contingency Management. The study lasts for 12 weeks of intervention, followed by a 12-week post-intervention follow-up period to monitor outcomes. During the study, participants will have their mean arterial pressure and endothelin-1 levels measured at various points, including baseline and several weeks into participation. Sleep quality is also assessed at baseline and during follow-up visits. Researchers will collect these data to understand the biopsychosocial effects of reduced methamphetamine use. Participants commit to regular visits and assessments throughout the 24-week total study duration.

Non-Abstinence Outcomes in Methamphetamine Use Disorder