Actively Recruiting
Non-Abstinence Outcomes in Methamphetamine Use Disorder
Led by William Stoops · Updated on 2026-01-23
300
Participants Needed
1
Research Sites
259 weeks
Total Duration
On this page
Sponsors
W
William Stoops
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Reduced drug use is a clinically meaningful target for treatment development, but few studies have evaluated the positive impacts produced by this behavioral change, preventing adoption of this endpoint in clinical trials. The proposed research will fill that critical knowledge gap by demonstrating the biopsychosocial benefits of reduced methamphetamine use. These data will be used to change current accepted methamphetamine treatment endpoints and accelerate identification of therapies for methamphetamine use disorder.
CONDITIONS
Official Title
Non-Abstinence Outcomes in Methamphetamine Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be age 18 years or older
- Self-report methamphetamine use in the week prior to screening
- Provide a methamphetamine-positive urine sample at screening
- Meet DSM-5 criteria for moderate-severe Methamphetamine Use Disorder
- Be seeking treatment for methamphetamine use
- Be able and willing to commit to the 12-week intervention and 12-week follow-up
- Individuals stably maintained on buprenorphine or methadone for Opioid Use Disorder are eligible
You will not qualify if you...
- Current or past medical or psychiatric illness that would interfere with participation, such as physical dependence on drugs other than buprenorphine requiring detoxification, unstable angina, uncontrolled cardiac arrhythmia, aortic stenosis, compromised immune function, severe substance use disorder other than MUD or treated OUD
- Poor venous access preventing blood draws
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Psychopharmacology of Addiction Laboratory
Lexington, Kentucky, United States, 40507
Actively Recruiting
Research Team
W
William W Stoops, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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