Optimization of Non-contrast Enhanced 1.5 Tesla and 3 Tesla Cardiac Magnetic Resonance Imaging Techniques and Acquisition of Normal Values

What this Trial Is About

Researchers are evaluating and optimizing cardiac magnetic resonance (MR) imaging techniques at 1.5 Tesla and 3 Tesla strengths without the use of contrast agents. The study focuses on improving image quality and adapting protocols based on individual patient anatomy and physiology. It aims to establish normal values for new cardiac MR imaging methods, including myocardial morphology, cardiac function, anatomy, and blood flow measurements. The study involves MR-compliant volunteers without a history of cardiovascular diseases. Various imaging sequences are used to assess normal myocardial morphology through T1-, T2-, and T2*-weighted imaging, cardiac function including systolic and diastolic performance, coronary artery anatomy, and blood flow characteristics such as velocity, vorticity, and timing. Data acquisition and protocol optimization are conducted without applying contrast agents. Participants undergo detailed cardiac MR scans within one week, during which multiple parameters like cardiac volumes, muscle mass, coronary artery anatomy, and various blood flow metrics are measured. The collected data help define normal ranges for magnetic relaxation times and cardiac function. The study involves healthy volunteers aged 18 to 80 years and includes screening for MR compatibility and ability to consent. Safety measures exclude individuals with metal implants, pregnancy, or claustrophobia.

Non-contrast Enhanced Cardiac Magnetic Resonance Normal Values and Imaging Protocols