Actively Recruiting
Non-Inferiority Trial of TrIGR for PTSD
Led by VA Office of Research and Development · Updated on 2025-06-26
158
Participants Needed
2
Research Sites
226 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Trauma-related guilt is common and impairing among trauma survivors, particularly among Veterans with posttraumatic stress disorder (PTSD). The investigators' work shows that a brief treatment targeting trauma-related guilt, Trauma Informed Guilt Reduction Therapy (TrIGR), can reduce guilt and PTSD and depression symptoms. Whether TrIGR is no less effective than longer, more resource heavy PTSD treatments disseminated by by VA, like cognitive processing therapy (CPT), is the next critical question that this study will seek to answer. 158 Veterans across two VA sites will be randomized to TrIGR or CPT to evaluate changes in PTSD, depression, guilt and shame symptoms across the two treatments.
CONDITIONS
Official Title
Non-Inferiority Trial of TrIGR for PTSD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- U.S. Veterans age 18 or older
- Meets diagnostic criteria for PTSD or subthreshold PTSD
- Scores 2 or higher on feeling trauma-related guilt much or all of the time or scores 3 or higher on at least one guilt cognition factor on the Trauma Related Guilt Inventory
- Not currently receiving trauma-focused treatment such as CPT or PE
- Willingness to attend psychotherapy and assessment sessions
You will not qualify if you...
- Impaired mental status as measured by the Montreal Cognitive Assessment (MoCA) with a score less than 21, confirmed by a neuropsychologist
- Significant current risk of suicidal or homicidal behavior
- Current severe substance use disorder in the past two months based on DSM-5 criteria
- Current unmanaged psychosis or mania
- Life threatening or unstable medical illness
- Inability to read
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States, 92161-0002
Actively Recruiting
2
James A. Haley Veterans' Hospital, Tampa, FL
Tampa, Florida, United States, 33612
Actively Recruiting
Research Team
S
Sonya B Norman, PhD
CONTACT
K
Kaitlyn Panza, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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