Actively Recruiting
Non-invasive Assessment for Outcome Prediction in Patients With Hepatocellular Carcinoma
Led by Chinese University of Hong Kong · Updated on 2025-06-29
159
Participants Needed
1
Research Sites
316 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single-centre, prospective cohort study. Consecutive patients with compensated liver disease and hepatocellular carcinoma (HCC) for curative-intent treatment will be invited to this study. The study follow-up duration will be five years. The primary outcome is the composite of incident high-risk varices, hepatic decompensation and liver-related mortality. The participants will undergo transient elastography at baseline and then half-yearly post-HCC curative treatment; and oesophagogastroduodenoscopy (OGD) at baseline and then at year 1, 3 and 5 post-HCC curative treatment. Clinical assessments and laboratory tests will also be done at baseline and every 6 months until year 5 to identify any clinical events.
CONDITIONS
Official Title
Non-invasive Assessment for Outcome Prediction in Patients With Hepatocellular Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 or above
- Known chronic liver disease(s)
- Hepatocellular carcinoma (HCC) planned for curative-intent treatment by surgery or local ablation
You will not qualify if you...
- Current or history of decompensated liver cirrhosis (such as Child's C cirrhosis or prior events like ascites, variceal bleeding, hepatic encephalopathy, hepatorenal syndrome)
- Past history of hepatocellular carcinoma (HCC) treated previously
- Non-primary liver tumors such as metastatic cancer to the liver
- History of or planned liver transplantation for HCC treatment
- Asplenism or previous splenectomy
- Contraindications to oesophagogastroduodenoscopy (OGD) like intestinal perforation or obstruction
- Serious illness with life expectancy less than 6 months
- Pregnancy
- Unable or unwilling to provide informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Prince of Wales Hospital
Hong Kong, Hong Kong
Actively Recruiting
Research Team
J
Jimmy CT Lai, MB ChB
CONTACT
A
Angel Chim, MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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