Actively Recruiting
Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease
Led by Chulalongkorn University · Updated on 2025-09-25
100
Participants Needed
1
Research Sites
125 weeks
Total Duration
On this page
Sponsors
C
Chulalongkorn University
Lead Sponsor
K
King Chulalongkorn Memorial Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Motor neuron disease (MND) is a progressive neurological disorder involving degeneration of motor neurons, leading to muscle weakness, speech and swallowing difficulties, and respiratory failure. This study aims to develop a novel treatment approach combining personalized repetitive transcranial magnetic stimulation (rTMS) with mixed reality (MR) exercise-based games (exergames) to slow disease progression and improve quality of life. In this randomised controlled trial study will compare three groups: (1) rTMS with MR exercise (personalized intervention), (2) rTMS with MR exercise (standard intervention), and (3) sham rTMS with MR exercise. Outcomes will be assessed at baseline, 3 months, and 6 months post intervention. The long-term goal is to implement this approach in clinical settings to enhance care for people with MND.
CONDITIONS
Official Title
Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged between 18 and 80 years
- Diagnosed with any type of motor neuron disease (MND)
- Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3
You will not qualify if you...
- History of other neurological disorders, such as stroke
- Use of ventilatory support
- Severe dementia
AI-Screening
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Trial Site Locations
Total: 1 location
1
King Chulalongkorn Memorial hospital, The Thai Red Cross Society
Bangkok, Pathumwan, Thailand, 10330
Actively Recruiting
Research Team
J
Jakkrit Amornvit, MD
CONTACT
P
Phunsuk Kantha, PT.,PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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