Non-invasive Zinc Protoporphyrin Measurement to Detect Iron Deficiency During and After Pregnancy Observational Study on Impact of Iron Deficiency on Maternal Health and Postpartum Outcomes

What this Trial Is About

Researchers are evaluating a new, non-invasive way to detect iron deficiency in pregnant women using a device that measures zinc protoporphyrin ZnPP through the skin of the lower lip. This study aims to compare this method with traditional blood tests and assess how iron deficiency during pregnancy affects postpartum depression, restless legs syndrome, pregnancy complications, and quality of life. The study is observational and follows participants over time to understand these relationships better. The study involves up to 500 pregnant women who will be assessed up to five times once in each trimester, at delivery, and 2-3 months after giving birth. During these visits, the ZnPP levels will be measured non-invasively with an optical sensor, and blood samples will be taken when possible to check standard iron and blood health markers. Participants will also complete questionnaires about their health, mood, restless legs symptoms, nutrition, supplement intake, and birth experience. Participants will be involved for up to 12 months, with assessments at key pregnancy and postpartum stages. Researchers will monitor the accuracy of the non-invasive ZnPP test compared to blood tests and expert diagnoses. They will also study how iron levels relate to fatigue, mood disorders, pregnancy outcomes, and newborn health. Safety and well-being are tracked through validated questionnaires and blood tests throughout the study period.

Non-invasive Detection of Iron Deficiency in Obstetrics