Actively Recruiting
Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device
Led by St. Antonius Hospital · Updated on 2026-02-17
40
Participants Needed
1
Research Sites
12 weeks
Total Duration
On this page
Sponsors
S
St. Antonius Hospital
Lead Sponsor
B
Burl Concepts, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn how well the SONAS ultrasound device can detect right-to-left shunts of adults with hereditary hemorrhagic telangiectasia (HHT) who are already scheduled for a contrast bubble echocardiogram (TTCE). The main questions it aims to answer are: 1. How accurately does SONAS detect right-to-left shunts compared to the standard TTCE test? 2. Can SONAS results help tell the difference between shunts in the heart and shunts in the lungs? Participants will wear a headband with the SONAS device on the head while they undergo their routine TTCE bubble test. They will receive the usual contrast (agitated saline) through a vein, and both SONAS and TTCE signals will be recorded at the same time. There will be one examination in rest, and one during a breathing exercise (the Valsalva manoeuvre).
CONDITIONS
Official Title
Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Suspected or confirmed hereditary hemorrhagic telangiectasia (HHT)
- Patients who have experienced cryptogenic stroke (incidental)
You will not qualify if you...
- Pregnancy or breastfeeding
- Known or suspected fractures of the temporal or parietal skull bones, or open skin injuries in those areas
- Known metal skull implants or head/ear anatomy that prevents proper headset placement
- Known allergies or reactions to parabens in the gel pad material
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Antonius Hospital
Nieuwegein, Utrecht, Netherlands, 3435CM
Actively Recruiting
Research Team
P
Pier HJ van Veen, Medical Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here