Pilot Study of Non-Invasive CT and MRI Scans to Diagnose Coronary Microvascular Disease in Patients with Chest Pain

What this Trial Is About

Researchers are investigating the use of new non-invasive imaging techniques to diagnose coronary microvascular disease CMD, a condition affecting the hearts small vessels that can cause chest pain and major heart events. CMD is often found in patients with stable chest pain but no significant blockage in the main heart arteries. Current diagnosis relies on invasive coronary angiography, which can be uncomfortable and risky, so this study aims to find safer, non-invasive alternatives using CT and MRI scans. Participants already involved in a main study comparing cardiac MRI and CT scans for coronary artery disease will join this pilot study. They will undergo additional invasive tests during their angiography to diagnose CMD. Following this, participants will have MRI scans that include advanced imaging techniques and exercise MRI, where they exercise using a cycle or stepping machine during the scan. The study will also analyze previously collected CT images to assess their ability to detect CMD compared to invasive tests. Throughout the study, participants will undergo various assessments including invasive coronary physiological tests, advanced MRI scans at rest and during exercise, and CT image analysis. Researchers will measure parameters like coronary luminal volume to myocardial mass ratio and blood oxygen level-dependent signals to evaluate their effectiveness in identifying CMD. The study includes safety monitoring and aims to gather data that could lead to improved non-invasive diagnosis and management of CMD over the long term.

Non-invasive Diagnosis of Coronary Microvascular Disease: Pilot Study