Actively Recruiting
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Led by Arkansas Children's Hospital Research Institute · Updated on 2024-09-25
400
Participants Needed
33
Research Sites
426 weeks
Total Duration
On this page
Sponsors
A
Arkansas Children's Hospital Research Institute
Lead Sponsor
C
Children's Hospital of Philadelphia
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will establish a non-invasive diagnostic approach and evaluate clinical outcomes for children at high-risk for pulmonary invasive fungal infection (PIFI).
CONDITIONS
Official Title
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males or females age > 120 days and < 22 years at any participating site
- Have at least one of the following conditions associated with a known high incidence of IFI: hematopoietic stem cell transplantation (HSCT), aplastic anemia, bone marrow failure, primary or acquired immune deficiency, or malignancy
- New (last 96 hours) radiographic evidence of at least one of the following: at least one nodular lesion greater than or equal to 5 mm in size, a wedge-shaped and segmental or lobar consolidation, a cavitary lesion, a lesion with a halo sign, a lesion with a reverse halo sign, or a lesion with an air crescent sign
- Prolonged neutropenia (absolute neutrophil count < 500 cells/µl for a period of ≥ 5 consecutive days) in 30 days prior to and including the day of qualifying chest MRI or CT scan date OR currently receiving systemic therapy for acute or chronic graft-versus-host disease (GVHD) OR presence of neutrophil dysfunction because of underlying acquired or primary immune deficiency (e.g. chronic granulomatous disease) on the date of the qualifying chest MRI or CT scan
- Subject consent or parental/guardian permission (informed consent) and if appropriate, child assent
You will not qualify if you...
- Weight <3 kg, so as to not exceed 3 ml/kg in a single blood draw
- Previous inclusion in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 33 locations
1
Arkansas Children's Research Institute
Little Rock, Arkansas, United States, 72202
Actively Recruiting
2
Rady Children's Hospital, UCSD
La Jolla, California, United States, 92093
Actively Recruiting
3
Children's Hospital of Orange County
Orange, California, United States, 92868
Actively Recruiting
4
Lucile Packard Children's Hospital, Stanford University
Palo Alto, California, United States, 94305
Actively Recruiting
5
University of California San Francisco, Benioff Children's Hospital
San Francisco, California, United States, 94143
Withdrawn
6
Yale University
New Haven, Connecticut, United States, 06520
Actively Recruiting
7
Children's National Hospital
Washington D.C., District of Columbia, United States, 20010-2916
Actively Recruiting
8
All Children's Research Institute
St. Petersburg, Florida, United States, 33701
Active, Not Recruiting
9
Emory University-Children's Healthcare of Atlanta (CHOA)
Atlanta, Georgia, United States, 30322
Actively Recruiting
10
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
11
University of Chicago Medicine, Comer Children's
Chicago, Illinois, United States, 60637
Actively Recruiting
12
Indiana University School of Medicine
Indianapolis, Indiana, United States, 46202
Actively Recruiting
13
Boston Children's Hospital
Boston, Massachusetts, United States, 02241
Actively Recruiting
14
University of Minnesota Medical School
Minneapolis, Minnesota, United States, 55455
Active, Not Recruiting
15
Children's Minnesota
Saint Paul, Minnesota, United States, 55102
Actively Recruiting
16
Children's Mercy
Kansas City, Missouri, United States, 64108
Actively Recruiting
17
The Washington University
St Louis, Missouri, United States, 63110
Actively Recruiting
18
Children's Omaha
Omaha, Nebraska, United States, 68114
Actively Recruiting
19
Weil Cornell Medical College
New York, New York, United States, 10021
Actively Recruiting
20
Duke University Medical Center
Durham, North Carolina, United States, 27710
Active, Not Recruiting
21
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
Actively Recruiting
22
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Withdrawn
23
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205-2664
Actively Recruiting
24
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
25
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19146
Actively Recruiting
26
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
27
Monroe Carell Jr. Children's Hospital at Vanderbilt
Nashville, Tennessee, United States, 37232
Actively Recruiting
28
Ascension Seton Medical Center
Austin, Texas, United States, 78705
Actively Recruiting
29
University of Texas Southwest Medical Center (UTSW)
Dallas, Texas, United States, 75390
Actively Recruiting
30
MD Anderson
Houston, Texas, United States, 77030
Actively Recruiting
31
Seattle Children's Research Institute
Seattle, Washington, United States, 98105
Actively Recruiting
32
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
33
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1E8
Actively Recruiting
Research Team
P
PFN Central Coordinator
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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