Actively Recruiting
Non Invasive Imaging Methods for Detecting PA：a Clinical PET Study of 18F-Pentixather
Led by Fangfang Sun · Updated on 2024-09-03
20
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Primary aldosteronism (PA) is the most common endocrine cause of hypertension. 68Ga-pentixafor PET/CT possesses a relatively high sensitivity and specificity for Aldosterone producing adenoma (APA) detection. However, 68Ga is usually eluted from a 68Ge-68Ga generator, only a small amount of isotopes can be achieved once time. \[18F\]AlF-chelation is a promising strategy that would solve these issues. 18F labeled Pentixafor-Based Imaging Agent(\[18F\]AlF-NOTA-Pentixather) has been reported by Andreas Poschenrieder. \[18F\]AlF-NOTA-Pentixather displayed high and CXCR4-specific in vivo uptake in Daudi xenografts (13.9%±0.8% injected dose per gram \[ID/g\] at 1 hour post injection\[p.i.\]). But to date 18F-Pentixather has not been studied in humans. In this program the investigators will estimate the radiation dosimetry of \[18F\]AlF-NOTA-Pentixather, evaluate the sensitivity and specificity of the \[18F\]AlF-NOTA-Pentixather as a probe for APA.
CONDITIONS
Official Title
Non Invasive Imaging Methods for Detecting PA：a Clinical PET Study of 18F-Pentixather
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with primary aldosteronism and willing to undergo surgery
- Clinically highly suspected of primary aldosteronism, but the diagnostic test cannot clearly identify the patients
- Postoperative recurrence in patients with primary aldosteronism
You will not qualify if you...
- Pregnant and lactating women
- Patients with poor autonomous behavior ability, severe claustrophobia, or critically ill patients requiring life support who cannot cooperate with the examination
- Other situations where patients are not suitable for this examination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China, 116022
Actively Recruiting
Research Team
F
Fangfang Sun, MD
CONTACT
W
Wei Song, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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