Actively Recruiting
Non-invasive Monitoring of Miscarriage
Led by Chinese University of Hong Kong · Updated on 2024-11-12
150
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research focuses on miscarriage in the first trimester, particularly examining the usefulness of cell-free DNA (cfDNA) in early pregnancy. The study aims to determine cfDNA levels and compare these results with product of conception (POC) testing and standard karyotyping. It highlights that pregnancies achieved by assisted reproductive technologies (ART) are closely monitored, while spontaneous abortion rates in natural conceptions are harder to assess. Women undergoing ART may have a higher vulnerability to miscarriage, making this research important for understanding chromosomal causes. Participants will not receive any treatment or intervention as this is an observational study involving routine procedures. The study involves monitoring and testing cfDNA levels and comparing these with genetic analysis of pregnancy tissue. The primary and secondary outcome measures will be evaluated at 15 weeks of pregnancy. During the study, women attending early pregnancy loss clinics or those who have received ART, along with their partners, will have their cfDNA levels measured and compared to POC testing results. Researchers will collect data through blood tests and genetic analyses without providing interventions. The total participation timeline includes assessments up to 15 weeks of pregnancy to monitor cfDNA and aneuploidy results, ensuring close observation of early pregnancy loss.
CONDITIONS
Brief Title
Non-invasive Monitoring of Miscarriage
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-45 years
- Women who attend the early pregnancy loss clinic or patients who receive assisted reproductive technology (ART)
- Biological partners of the pregnancy
You will not qualify if you...
- History of psychological or psychiatric problems
- Patient refusal
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 15 weeks
Participants undergo blood tests to measure cell-free DNA levels and product of conception testing in early pregnancy loss.
1 to 2 visits depending on pregnancy status
Duration - Up to 15 weeks
Participants are observed to collect data on miscarriage outcomes and cfDNA levels over time without additional intervention.
Follow-up visits as needed during the observation period
Trial Site Locations
Total: 1 location
1
Prince of Wales Hospital
Hong Kong, Hong Kong
Actively Recruiting
Research Team
P
PUI WAH JACQUELINE CHUNG
Y
Yee Lee Elaine NG
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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