Non-invasive Phrenic Nerve Stimulation in ARDS Patients - a Feasibility Study

What this Trial Is About

Reduced diaphragmatic activity during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) can cause diaphragm weakening, lung collapse, increased lung stress, and blood flow problems. These issues may extend the time on ventilators, complicate weaning, and raise mortality risk. Researchers are exploring whether synchronized phrenic nerve stimulation can help maintain diaphragm function, prevent ventilator-related injuries, and improve outcomes. While implanted phrenic nerve stimulation is used in some neurological disorders, its effects in ARDS patients on mechanical ventilation need further study. The study evaluates a non-invasive device that delivers electrical stimulation to the phrenic nerve in ARDS patients on mechanical ventilation. This stimulation is synchronized to encourage diaphragm activity during ventilation. The intervention aims to reduce ventilator-induced lung and diaphragm damage. Patients receive this non-invasive phrenic nerve stimulation while undergoing usual mechanical ventilation care throughout the treatment period. Participants will be monitored from enrollment until extubation, with researchers measuring how often adequate tidal volumes are achieved and how quickly the stimulation device is successfully applied. Additional assessments include diaphragm thickness and movement, maximal inspiratory pressure, lung ventilation distribution, driving pressure, and respiratory system compliance. Safety and feasibility data will be collected to understand how this approach affects patient breathing and diaphragm function during ventilated support.

Non-invasive Phrenic Nerve Stimulation in ARDS Patient