Actively Recruiting
Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies
Led by IRCCS Ospedale San Raffaele · Updated on 2026-03-27
51
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to define the importance of non-invasive programmed stimulation (NIPS) in risk stratification of ventricular tachycardia (VT) recurrence after catheter ablation and to determine the optimal treatment strategy. The primary objective is to establish whether a new VT ablation based on NIPS inducibility will reduce the risk of VT recurrence compared to antiarrhythmic drug therapy.
CONDITIONS
Official Title
Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with an implanted ICD (all brands)
- Patients who underwent a successful ventricular tachycardia ablation procedure with non-inducibility of any VT supported by EnSite Precision or CARTO 3D mapping systems for previous MI, myocarditis, ARVD, or IDCM
- Induction of monomorphic VT at NIPS 3-7 days after a successful ablation
- Age 18 years or older
- Able to provide informed consent and follow study assessments
You will not qualify if you...
- Inducible VT after index procedure
- Contraindication to anticoagulants
- Presence of thrombi
- Presence of mitral and aortic prosthetic valve
- Recent (less than 3 months) myocardial infarction, unstable angina, or coronary artery bypass
- Pregnant or nursing
- Ventricular tachycardia caused by reversible pathology
- Life expectancy less than 1 year according to investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
San Raffaele Hospital, Arrhythmology and Electrophysiology unit
Milan, Italy, Italy, 20132
Actively Recruiting
Research Team
A
Andrea Radinovic, MD
CONTACT
A
Anna Montagna, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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