Actively Recruiting
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
Led by University of Wisconsin, Madison · Updated on 2026-05-06
55
Participants Needed
1
Research Sites
54 weeks
Total Duration
On this page
Sponsors
U
University of Wisconsin, Madison
Lead Sponsor
N
Neuraworx Medical Technologies
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain. The modulated blood flow will restore the flow of cerebrospinal fluid (CSF) and this in turn can help improve waste clearance in the brain and prevent build up that may lead to disease.
CONDITIONS
Official Title
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 20 to 85 years for healthy participants
- Willing and able to undergo all study procedures
- No neurological, neuropsychiatric, developmental, or other medical conditions as determined by investigators
- Age 20 to 65 years for participants with mild traumatic brain injury
- Diagnosed with mild traumatic brain injury within 1 to 52 weeks post-injury
- Willing and able to undergo all study procedures
You will not qualify if you...
- Contraindications to MRI
- Known allergies to common electrode materials
- Use of cardiovascular medications that could affect glymphatic function (e.g., ACE-inhibitors, angiotensin receptor blockers, calcium channel blockers) for mTBI participants
- Chronic infectious diseases such as hepatitis, HIV, or tuberculosis
- Diagnosed with small vessel disease, vascular dementia, or renal disease
- Retinopathies or neuropathies that may interfere with study completion or glymphatic function
- Neurological disorders other than primary diagnosis, such as multiple sclerosis, Parkinson's disease, ALS, Alzheimer's disease, or uncontrolled pain
- History of penetrating brain injury, craniotomy (except burr hole for acute subdural hematoma), or refractory subdural hematoma
- History of seizures except controlled acute or post-acute phase seizures
- Loss of consciousness longer than 24 hours from traumatic brain injury
- Inability to feel sensory sensations from stimulation or to complete electrode placement and testing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Wisconsin - Madison
Madison, Wisconsin, United States, 53705
Actively Recruiting
Research Team
N
Neurosurgery Research
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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