Actively Recruiting
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
Led by Washington University School of Medicine · Updated on 2026-04-13
65
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.
CONDITIONS
Official Title
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients who present with acute ischemic strokes due to large vessel occlusions
You will not qualify if you...
- Under 18 years old
- Patients with presumed chronic large vessel occlusions
- NIH Stroke Scale score less than 6
- Pre-stroke modified Rankin score greater than 2
- Unable to start treatment within 24 hours of symptom discovery
- Chronic or acute infection, recent surgery, active immune disease
- Life expectancy less than 3 months
- Receiving active cancer or immunosuppressive/modulating therapy
- Sustained bradycardia on arrival with heart rate less than 50 beats per minute
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Barnes-Jewish Hospital
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
A
Angela Birke, MS
CONTACT
O
Osvaldo Laurido-Soto, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here