Actively Recruiting
Non-invasive Ventilation in Reducing the Need for Intubation in Patients With Cancer and Respiratory Failure
Led by M.D. Anderson Cancer Center · Updated on 2026-03-05
256
Participants Needed
1
Research Sites
573 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized clinical trial studies how well non-invasive ventilation works in reducing the need for intubation, or placement of a tube in the windpipe, in patients with cancer and respiratory failure. Respiratory failure is a condition in which not enough oxygen passes from the lungs to the blood, and is a common cause of admission to the emergency room in patients with hematological and solid tumor patients. Non-invasive positive pressure ventilation (NIPPV) is a method of delivering oxygen using a mask. It is not yet known whether NIPPV is better at improving the amount of oxygen in the blood, reducing shortness of breath, and the need for intubation than standard high flow oxygen (a tube with 2 prongs placed in the nostrils) in patients with cancer and respiratory failure.
CONDITIONS
Official Title
Non-invasive Ventilation in Reducing the Need for Intubation in Patients With Cancer and Respiratory Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Partial pressure of arterial oxygen to fraction of inspired oxygen ratio (PaO2:FiO2) of 300 mmHg or less, or peripheral capillary oxygen saturation to FiO2 ratio (SaO2:FiO2) of 357 or less
- Diagnosis of any malignancy
- Chest X-ray or CT scan within 3 months before enrollment showing no active or metastatic lung or pleural cancer causing breathing problems
- Expected survival of at least 6 months
You will not qualify if you...
- Presence of do not resuscitate (DNR) or do not intubate (DNI) orders at enrollment
- Heart failure as the main cause of respiratory problems
- Active lung or pleural cancer causing breathing problems
- Acute exacerbation of chronic obstructive pulmonary disease as main cause of respiratory failure
- Use of accessory muscles to breathe
- Shock requiring vasopressors or low blood pressure despite fluids
- Acute kidney failure with very low urine output unless on dialysis
- Already using NIPPV at screening
- Blood pH below 7.30 or high carbon dioxide levels (pCO2 > 50)
- Fixed upper airway blockage
- Facial or airway injury preventing NIPPV mask use
- Uncontrolled abnormal heart rhythms or active heart attack
- Glasgow Coma Scale below 8 or poor airway reflexes
- Undrained pneumothorax or pneumomediastinum
- Excessive sputum or significant bleeding from lungs
- Risk of stomach contents entering lungs
- Recent stomach or bowel surgery within 3 weeks
- Unable or unwilling to use NIPPV
- Respiratory arrest
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
N
Nisha Rathi, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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