Comparing Standard Non-Invasive Ventilation and NAVA Mode for Treating Bronchiolitis in Children Under 2 Years

What this Trial Is About

This research aims to find out if using Neurally-Adjusted Ventilatory Assistance NAVA mode for non-invasive ventilation in children with bronchiolitis improves their comfort and reduces the need for more intense treatments like intubation compared to standard non-invasive ventilation. Bronchiolitis is a common lung infection in young children that can cause breathing difficulties. NAVA has been shown to better match the ventilator support with the childs breathing efforts, which may lead to better breathing support. The study compares two non-invasive ventilation methods the standard mode and the NAVA mode. The NAVA method uses a special catheter placed in the esophagus to monitor the electrical activity of the diaphragm, allowing the ventilator to deliver pressure that matches the childs breathing effort more closely. Children will receive either standard non-invasive ventilation or NAVA ventilation according to the study protocol while in the Pediatric Intensive Care Unit. The researchers will track breathing scores and diaphragm activity to see how these methods affect breathing support and comfort. Participants will be monitored regularly for their respiratory status using a Respiratory Severity Score RSS and measurements of electrical activity in the diaphragm Edi. These assessments are taken about one hour after placing the catheter and then approximately every four hours over a 48-hour period. The study will also observe how long children need non-invasive ventilation, if they require intubation, and any need for increased ventilatory support or sedating medications. The study period lasts up to four weeks or until intubation if needed.

Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis