Actively Recruiting
Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis
Led by Montefiore Medical Center · Updated on 2025-09-05
130
Participants Needed
1
Research Sites
167 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This project aims to answer whether the use of a Neurally-Adjusted Ventilatory Assistance mode for non-invasive ventilation in pediatric patients with bronchiolitis results in improved comfort and reduced escalations in therapy (including intubation) when compared to using a standard mode of non-invasive ventilation. Neurally-Adjusted Ventilatory Assistance (NAVA) has been shown to result in greater synchrony then the standard mode of non-invasive ventilation. The study team hypothesizes that this improved synchrony can result in important clinical improvements when NAVA is used to treat children with bronchiolitis.
CONDITIONS
Official Title
Non-Invasive Ventilation Versus Neurally-Adjusted Ventilatory Assistance (NAVA) for the Treatment of Bronchiolitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients under the age of two years old with a diagnosis of bronchiolitis presenting to the pediatric ICU
- Patient's provider believes there is equipoise between the use of NAVA or conventional non-invasive ventilation for the patient
You will not qualify if you...
- Patients unable to utilize a nasogastric tube
- Patients with a diagnosis of chronic lung disease, cyanotic heart lesions, or congestive heart failure
- Patients with hypotonia
- Patients likely to require imminent intubation: >0.60 Fraction of Inspired Oxygen (FiO2); Carbon Dioxide (CO2) > 60, frequent apneas, clinician determines patient unlikely to tolerate non-invasive modality
- Patients with hemodynamic instability, defined as the need for vasoactive medication
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Hospital at Montefiore
The Bronx, New York, United States, 10467
Actively Recruiting
Research Team
J
Jacqueline Weingarten, MD
CONTACT
M
Monica Koncicki, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here