Actively Recruiting
Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes
Led by Virginia Polytechnic Institute and State University · Updated on 2025-12-04
30
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged/older adults with prediabetes is unknown, and potential mechanisms by which this could occur have yet to be identified. The overall objective of this R21 proposal is to establish proof-of-concept for alterations in glucose homeostasis following intake of sucralose, but not aspartame, in middle-aged/older adults with prediabetes compared to a eucaloric diet with no NNS.
CONDITIONS
Official Title
Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 40 years or older
- Prediabetic with fasting glucose 100-125 mg/dL, 2-hour oral glucose tolerance test 140-199 mg/dL, or HbA1c 5.7% to 6.4%
- Weight stable within plus or minus 2 kg for the past 6 months
- Body mass index (BMI) less than 40 kg/m2
- Sedentary to recreationally active lifestyle
- No plans to gain or lose weight or change physical activity during the study
- Willing to pick up and eat only provided study foods daily for 8 weeks
- Able to provide verbal and written informed consent
- Approval by Medical Director
- Consumes less than one serving of non-nutritive sweetener per week
You will not qualify if you...
- Body mass index (BMI) greater than 40 kg/m2
- Diagnosis of diabetes or use of diabetes medication
- Use of antibiotics, prebiotics, or probiotics in the past 3 months
- Uncontrolled high blood pressure (greater than 159/99 mmHg)
- Diagnosed inflammatory bowel disease
- Past or current heart disease, stroke, respiratory disease, endocrine or metabolic disease, or blood cancers
- Vegetarian or vegan diet
- Pregnant or planning to become pregnant
- Breastfeeding
- Food allergies, food aversions, or phenylketonuria (PKU)
- Use of estrogen or testosterone therapy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Virginia Tech
Blacksburg, Virginia, United States, 24061
Actively Recruiting
Research Team
V
Valisa Hedrick, PhD
CONTACT
E
Elaina Marinik, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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