Actively Recruiting
Non-steroidal Anti-inflammatory in Cardiac Surgery
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2025-07-23
238
Participants Needed
1
Research Sites
170 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire, Amiens
Lead Sponsor
U
University Hospital, Rouen
Collaborating Sponsor
AI-Summary
What this Trial Is About
Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.
CONDITIONS
Official Title
Non-steroidal Anti-inflammatory in Cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Scheduled for cardiac surgery such as aortic valve replacement, coronary artery bypass graft, mitral valve repair or replacement, intracardiac tumor removal, or aortic root repair
- Surgery performed with cardiopulmonary bypass
- Affiliated with the French national healthcare system
- Written informed consent obtained
You will not qualify if you...
- Younger than 18 years old
- Weight less than 50 kg
- Chronic use of NSAIDs
- Mini-invasive surgery
- Contraindications or allergy to NSAIDs
- Contraindications to nefopam, paracetamol, or tramadol
- Urgent surgery
- Endocarditis
- Use of immunosuppressive drugs
- HIV infection with CD4 count below 200/mm3
- History of organ transplantation
- Stage 4 or 5 chronic kidney disease
- Gastro-duodenal ulcer
- Pregnancy
- Depression
- Autoimmune disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CHU Amiens Picardie
Amiens, France
Actively Recruiting
Research Team
O
Osama ABOU ARAB, Pr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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