Study of Non-steroidal Anti-inflammatory Drugs for Pain Control During Pleurodesis Surgery in Adults with Pneumothorax

What this Trial Is About

This research aims to evaluate the safety and pain management effects of non-steroidal anti-inflammatory drugs NSAIDs during pleurodesis surgery for pneumothorax. There is debate about using NSAIDs in this surgery because they might interfere with the pleurodesis process and increase the risk of pneumothorax coming back. The investigators believe NSAIDs can be safe and improve pain control without raising this risk. Participants will either receive ketoprofen, an NSAID, with one intravenous dose followed by five oral doses every 12 hours for 72 hours, or a placebo with a similar schedule. All patients will undergo pleurodesis surgery under general anesthesia with pain management options allowed at the doctors discretion. The study uses a double-blind, randomized design to compare these treatments. During the hospital stay, pain will be assessed every 12 hours using a pain scale. Researchers will monitor the duration of pleural drainage and track postoperative pain, opioid use, pneumonia occurrence, hospital stay length, and pneumothorax recurrence at multiple time points up to one year. Neuropathic pain will also be screened at 48 hours, 1 month, 6 months, and 1 year after treatment. The study participation may last up to 6 months or longer depending on follow-up.

Non-steroidal Anti-inflammatory Drugs in Pleurodesis