Actively Recruiting
Non-steroidal Anti-inflammatory Drugs in Pleurodesis
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2025-03-19
358
Participants Needed
1
Research Sites
195 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire, Amiens
Lead Sponsor
C
Centre Hospitalier VALENCIENNES
Collaborating Sponsor
AI-Summary
What this Trial Is About
Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use. However, there is a controversy in its use in pleurodesis surgery as it could block the process of pleurodesis in surgical pneumothorax. In addition, NSAIDs could increase the risk of pneumothorax recurrence. The investigators hypothesized that NSAIDs are safe during pleurodesis with a better pain management without increasing the risk of pneumothorax reccurence.
CONDITIONS
Official Title
Non-steroidal Anti-inflammatory Drugs in Pleurodesis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosis of pneumothorax with an indication for pleurodesis
- Pleurodesis performed with or without minimal lung resection
- Surgery done via thoracotomy or thoracoscopy
You will not qualify if you...
- Patients younger than 18 years
- Pregnant, parturient, or breastfeeding patients
- Severe polytrauma with Vittel criteria
- Purulent pleurisy
- Hemopneumothorax
- Lactose hypersensitivity
- Contraindications to NSAIDs
- Contraindications to tramadol
- Contraindications to paracetamol
- Receiving curative anticoagulation
- Under guardianship or deprived of liberty
- Patient refusal
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Centre Hospitalier Universitaire d'Amiens
Amiens, France, 80054
Actively Recruiting
Research Team
F
Florent LEVIEL, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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