Actively Recruiting
Nonalcoholic Steatohepatitis in Chinese Children
Led by Humanity and Health Research Centre · Updated on 2025-03-24
400
Participants Needed
1
Research Sites
578 weeks
Total Duration
On this page
Sponsors
H
Humanity and Health Research Centre
Lead Sponsor
B
Beijing 302 Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Nonalcoholic steatohepatitis (NASH) is now recognised as an increasing clinical problem in children. Steatosis without significant liver cell injury or fibrosis is the most common form of nonalcoholic fatty liver disease (NAFLD) in both adults and children. Studies in the adult population have variably suggested that steatosis is a benign nonprogressive condition and NASH is recognised as a potentially serious condition with significantly risk of morbidity and mortality. A growing body of evidence suggests that children with NASH frequently show histopathological features that differ from those of adults. The prevalence of this pattern in a wide range of paediatric cases as well as other histopathological lesions and their relevance and prognostic significance in children with NAFLD remains to be determined. Thus the investigators would like to conduct a study of biopsies and clinical information to document the histological features of paediatric NAFLD, to explore the natural history of paediatric NAFLD, and to determine the frequency and prognostic value of these features.
CONDITIONS
Official Title
Nonalcoholic Steatohepatitis in Chinese Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 1 to 18 years with biopsy-proven nonalcoholic fatty liver disease (NAFLD)
- Alcohol consumption less than 20 grams per day for boys and less than 10 grams per day for girls
You will not qualify if you...
- Diagnosis of viral hepatitis, such as HBV or HCV
- Diagnosis of a1-anti-trypsin disease
- Diagnosis of autoimmune hepatitis
- Diagnosis of Wilson disease
- Liver impairment caused by drugs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Liver Disease Center, 302 Hospital
Beijing, China
Actively Recruiting
Research Team
G
George Lau, MD, PhD
CONTACT
Y
Yudong Wang, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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