Actively Recruiting
Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome
Led by Spaulding Rehabilitation Hospital · Updated on 2026-02-20
95
Participants Needed
1
Research Sites
306 weeks
Total Duration
On this page
Sponsors
S
Spaulding Rehabilitation Hospital
Lead Sponsor
H
Highland Instruments, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to assess the effects of tDCS in combination with TUS for the treatment of pain in subjects with Carpal Tunnel Syndrome. The investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation.
CONDITIONS
Official Title
Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide informed consent to participate in the study
- Aged between 18 to 80 years
- Symptomatic Carpal Tunnel Syndrome with symptoms spreading within or beyond the median nerve area involving at least one wrist
- Chronic pain lasting at least 6 months, present on at least half the days in the past 6 months, with an average pain score of at least 3 on a 0-10 scale
- Pain resistant to first line therapies, with pain still present most of the time after treatment
- Ability to feel pain as self-reported
You will not qualify if you...
- Pregnant
- Contraindications to tDCS and TUS, including intracranial metal implants or implanted brain medical devices
- History of alcohol or drug abuse within the past 6 months
- Use of carbamazepine within the past 6 months
- Major depression with PHQ-9 score of 20 or higher
- History of neurological disorders such as stroke, brain tumors, or epilepsy with residual symptoms
- Abnormal EEG activity at baseline
- History of unexplained fainting spells
- History of head injury causing more than momentary loss of consciousness with current neurological deficits
- History of intracranial neurosurgery
AI-Screening
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Trial Site Locations
Total: 1 location
1
Spaulding Rehabilitation Network Research Institute
Charlestown, Massachusetts, United States, 02129
Actively Recruiting
Research Team
F
Felipe Fregni, MD PhD mph
CONTACT
M
Meghan Whalen, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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