Early Noninvasive Detection of Lung Transplant Rejection Using Multiple Breath Washout Test and Lung Clearance Index

What this Trial Is About

Chronic rejection after lung transplantation, known as bronchiolitis obliterans syndrome BOS, is a leading cause of death beyond the first year post-transplant. This research aims to evaluate the use of lung clearance index LCI, measured by multiple breath washout MBW tests, as an early marker for BOS. Early detection could allow treatment changes before lung function worsens, potentially improving survival for lung transplant recipients. The study includes patients who have undergone bilateral lung transplantation at Zurich University Hospital. Participants will have LCI measurements using the EXHALYZERD with Nitrogen Washout System performed monthly, starting 3 months after their lung transplant. This follow-up continues for 5 years or longer as needed. The MBW test tracks the washout of nitrogen from the lungs during relaxed breathing, helping detect early airway disease before it appears on conventional lung function tests. During the study, researchers will regularly assess lung function and LCI to monitor early signs of BOS. They will measure LCI and forced expiratory volume in 1 second FEV1 over the 5-year period. These evaluations aim to identify BOS development earlier than usual methods, enabling timely treatment. Participants are involved in monthly testing and long-term monitoring to support improved outcomes after lung transplantation.

Noninvasive Early Detection of Lung Allograft Dysfunction After Lung Transplantation With Multiple Breath Washout Test