Actively Recruiting
Noninvasive Technique and High Flow Nasal Oxygen in Respiratory Failure
Led by Minia University · Updated on 2026-04-09
75
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
Sponsors
M
Minia University
Lead Sponsor
M
Minia University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
After obtaining Institutional Ethical Committee approval of Faculty of Medicine, Minia University and written informed consent from patients or first- degree relatives, this prospective randomized non-blind comparative study will be conducted in adult intensive care unit (ICU) of Anesthesia, Intensive Care and Pain management department Minia university hospital over a period from September 2025 to April 2026. This study is designed to compare the effectiveness of two protocols of sequential use of High Flow Nasal Cannula (HFNC) and noninvasive ventilation (NIV) versus NIV alone in patients with Acute Respiratory failure (ARF) admitted to the intensive care unit (ICU). The study will include 75 patients of both sexes, classified as ASA class Ⅰ-ⅠⅠⅠ, divided into three groups with 25 patients in each group.
CONDITIONS
Official Title
Noninvasive Technique and High Flow Nasal Oxygen in Respiratory Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older of both sexes
- Diagnosis of Acute Respiratory Failure defined by PaO2/FiO2 ratio less than 300 after 15 minutes of conventional oxygen at FiO2 ≥ 50% and respiratory rate over 30 breaths per minute
You will not qualify if you...
- Chronic respiratory disease
- Cardiogenic pulmonary edema
- Life-threatening arrhythmias
- Hemodynamic instability requiring vasopressors
- Facial abnormalities preventing NIV or HFNC use
- Glasgow Coma Score 12 or less
- Agitation with Richmond Agitation Sedation Scale score 2 or higher
- Need for immediate endotracheal intubation
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Minya university hospitals
Minya, Minya Governorate, Egypt
Actively Recruiting
Research Team
O
Omyma S Mohamed, Prof.
CONTACT
S
Shadwa R Mohamed, Ass. Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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