Actively Recruiting
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor
Led by University of Calgary · Updated on 2026-05-01
12
Participants Needed
1
Research Sites
573 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study to evaluate the safety and efficacy of a nonmyeloablative conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients with sickle cell disease (SCD) who have a matched related major ABO-incompatible donor. The nonmyeloablative regimen will use alemtuzumab, total body irradiation (TBI) and sirolimus for immune suppression. This study will expand the access of HSCT for patients with SCD who are currently not eligible because of donor restrictions.
CONDITIONS
Official Title
Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be 1 year or older and younger than 19 years at enrollment
- Diagnosis of sickle cell disease confirmed by hemoglobin electrophoresis, including HbSS, HbSC, HbS/beta-plus-thalassemia, or HbS/beta-zero-thalassemia
- Patients must meet standard criteria for stem cell transplant including one or more of the following: multiple vaso-occlusive crises, history of stroke, elevated transcranial Doppler velocity not eligible for hydroxyurea, acute chest syndrome, splenic sequestration crisis, priapism in males, osteonecrosis, pulmonary hypertension, or red cell allo-immunization
- Sickle cell complications may be present despite hydroxyurea use or if the patient is considered high risk for further crises by their doctor
You will not qualify if you...
- Inability to comply with or follow the study protocol
- Known allergy or hypersensitivity to sirolimus or its components
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Alberta Children's Hospital
Calgary, Alberta, Canada, T3B 6A8
Actively Recruiting
Research Team
T
Tony Truong, MD, MPH
CONTACT
G
Greg Guilcher, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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