Actively Recruiting
NOPE37: Angiogenic Factors for Managing Term Preeclampsia
Led by Hospital Universitari Vall d'Hebron Research Institute · Updated on 2025-12-11
750
Participants Needed
23
Research Sites
121 weeks
Total Duration
On this page
Sponsors
H
Hospital Universitari Vall d'Hebron Research Institute
Lead Sponsor
I
Instituto de Salud Carlos III
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study tests the hypothesis that, in women with preeclampsia without severe features, delivery management based on sFlt-1/PlGF would reduce the rate of induction of labor without worsening the rate of progression to preeclampsia with severe features and other maternal complications.
CONDITIONS
Official Title
NOPE37: Angiogenic Factors for Managing Term Preeclampsia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Singleton pregnancy
- Preeclampsia without severe features according to the ACOG definition
- Antegrade diastolic flow in the umbilical artery Doppler
- Gestational age between 36 weeks 0 days and 38 weeks 6 days
- Gestational age confirmed by fetal crown-rump length measurement in the first trimester (11 weeks 0 days to 13 weeks 6 days) or by in vitro fertilization dates
You will not qualify if you...
- Fetal death
- Preeclampsia with severe features according to the ACOG definition, eclampsia, or any condition requiring immediate delivery
- Absent or reversed end-diastolic flow in the umbilical artery Doppler
- Non-reassuring cardiotocography (CTG)
- Decreased fetal movements
- Biophysical profile score 6 or less
- Oligohydramnios (low amniotic fluid)
- Refusal to provide informed consent
- Fetal malformation
- Placental abruption
- Antiphospholipid antibody syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 23 locations
1
Hospital Universitari Dexeus
Barcelona, BARCELONA, Spain, 08024
Actively Recruiting
2
Hospital Universitario de A Coruña
A Coruña, Spain
Actively Recruiting
3
Hospital General Universitari Dr. Balmis
Alicante, Spain
Actively Recruiting
4
Vall d'Hebron Hospital Campus
Barcelona, Spain
Actively Recruiting
5
Hospital Universitario de Cabueñes
Cabueñes, Spain
Actively Recruiting
6
Hospital Universitario Puerta del Mar
Cadiz, Spain
Actively Recruiting
7
Hospital General Universitario de Elche
Elche, Spain
Actively Recruiting
8
Hospital Universitario de Getafe
Getafe, Spain
Actively Recruiting
9
Hospital Universitari de Girona Doctor Josep Trueta
Girona, Spain
Actively Recruiting
10
Hospital Universitario San Cecilio
Granada, Spain
Actively Recruiting
11
Hospital Universitario de Jerez
Jerez de la Frontera, Spain
Actively Recruiting
12
Hospital Materno Infantil de Gran Canaria
Las Palmas de Gran Canaria, Spain
Actively Recruiting
13
Hospital Universitari Arnau de Vilanova
Lleida, Spain
Actively Recruiting
14
Hospital universitario 12 de Octubre
Madrid, Spain
Actively Recruiting
15
Hospital Clínico Universitario Virgen de la Arrixaca
Murcia, Spain
Actively Recruiting
16
Hospital Universitari Son Espases
Palma de Mallorca, Spain
Actively Recruiting
17
Hospital Universitario Virgen de Valme
Seville, Spain
Actively Recruiting
18
Hospital Universitario Virgen Macarena
Seville, Spain
Actively Recruiting
19
Hospital Universitari de Tarragona Joan XXIII
Tarragona, Spain
Actively Recruiting
20
Consorci Sanitari de Terrassa
Terrassa, Spain
Actively Recruiting
21
Hospital Universitari MútuaTerrassa
Terrassa, Spain
Actively Recruiting
22
Hospital Universitario de Torrejón
Torrejón, Spain
Actively Recruiting
23
Hospital Universitario Lozano Blesa
Zaragoza, Spain
Actively Recruiting
Research Team
E
Erika Bonacina, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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