Actively Recruiting
Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery
Led by Jagiellonian University · Updated on 2026-01-14
750
Participants Needed
5
Research Sites
105 weeks
Total Duration
On this page
Sponsors
J
Jagiellonian University
Lead Sponsor
M
Medical Research Agency, Poland
Collaborating Sponsor
AI-Summary
What this Trial Is About
The effect of noradrenaline infusion versus standard blood pressure management on perioperative HYPotension in NOn-caRdiac surgery. The study aims to determine whether perioperative noradrenaline infusion is superior to standard blood pressure management for the occurrence of perioperative hypotension.
CONDITIONS
Official Title
Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 45 years or older
- Elective or accelerated non-cardiac surgery expected to last at least 1 hour
- Surgery requiring general, neuraxial, or combined general with neuraxial anesthesia
- Expected hospital stay overnight after surgery
- Written informed consent provided
- American Society of Anesthesiologists (ASA) physical status class II or higher
You will not qualify if you...
- Newly diagnosed, untreated, or uncontrolled hypertension with systolic blood pressure 6180 mm Hg or diastolic blood pressure 6110 mm Hg in two measurements the day before surgery
- Persistent systolic blood pressure difference over 10 mm Hg between right and left arms
- Persistent atrial fibrillation
- History of dementia
- Language, vision, or hearing impairments affecting cognitive assessments
- Conditions preventing routine blood pressure management such as surgeon request for relative hypotension
- Use of irreversible nonselective monoamine oxidase inhibitors within 2 weeks before enrollment
- Use of tricyclic antidepressants
- Diagnosis of Prinzmetal angina
- Contraindications to noradrenaline as judged by clinician
- Noradrenaline infusion started before surgery or planned continuous infusion throughout surgery
- Physician decision for extended continuous hemodynamic monitoring during or after surgery
- Severe kidney disease with creatinine clearance <15 mL/min/1.73m2 or on renal replacement therapy
- End-stage heart failure classified as NYHA Class IV
- Severe liver disease including cirrhosis or signs of liver dysfunction
- Emergency or urgent surgery within 24 hours of sudden illness or unplanned hospital admission
- Previous participation in this trial
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 5 locations
1
Uniwersyteckie Centrum Kliniczne im. Prof. Kornela Gibińskiego Śląski Uniwersytet Medyczny
Katowice, Poland, 40-752
Actively Recruiting
2
5 Wojskowy Szpital Kliniczny z Polikliniką Samodzielny Publiczny Zakład Opieki Zdrowotnej w Krakowie
Krakow, Poland, 30-901
Actively Recruiting
3
Wojewódzki Szpital Specjalistyczny w Olsztynie
Olsztyn, Poland, 10-561
Active, Not Recruiting
4
Uniwersytecki Szpital Kliniczny w Opolu
Opole, Poland, 45-401
Actively Recruiting
5
Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Stanisława Szyszko Śląskiego Uniwersytetu Medycznego w Katowicach
Zabrze, Poland, 41-800
Actively Recruiting
Research Team
B
Bożena Seczyńska, PhD
CONTACT
Z
Zbigniew Putowski, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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