Actively Recruiting
Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer
Led by Tampere University Hospital · Updated on 2025-09-02
200
Participants Needed
13
Research Sites
450 weeks
Total Duration
On this page
Sponsors
T
Tampere University Hospital
Lead Sponsor
T
Tampere University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this one-arm clinical trial is to implement and study the oncological outcomes of nonoperative management of rectal cancer having complete clinical response to neoadjuvant therapy. The main questions to answer are * if the oncological results of nonoperative management after Nordic practice in chemoradiotherapy indications differ from experiences elsewhere * what is the organ preservation rate * what is the local regrowth rate
CONDITIONS
Official Title
Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histopathological verification of primary rectal adenocarcinoma
- Complete clinical response at response assessment after neoadjuvant therapy
- Informed consent to organ preservation study
You will not qualify if you...
- Evidence of metastatic disease (fulfilling M-class criteria of TNM)
- No neoadjuvant therapy
- Inability to understand the information related to harms and benefits
AI-Screening
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Trial Site Locations
Total: 13 locations
1
East Tallinn Central Hospital
Tallinn, Estonia
Actively Recruiting
2
North Estonia Medical Centre
Tallinn, Estonia
Actively Recruiting
3
West Tallinn Central Hospital
Tallinn, Estonia
Actively Recruiting
4
Tartu University Hospital
Tartu, Estonia
Actively Recruiting
5
Helsinki University Central Hospital
Helsinki, Finland, 00290
Actively Recruiting
6
Jyväskylä Central Hospital
Jyväskylä, Finland
Actively Recruiting
7
Kuopio University Hospital
Kuopio, Finland
Actively Recruiting
8
Oulu University Hospital
Oulu, Finland
Actively Recruiting
9
Satakunta Central Hospital
Pori, Finland
Actively Recruiting
10
Seinajoki Central Hospital
Seinäjoki, Finland
Actively Recruiting
11
Tampere University Hospital
Tampere, Finland, 33400
Actively Recruiting
12
Turku University Hospital
Turku, Finland
Actively Recruiting
13
Vaasa Central Hospital
Vaasa, Finland, 65100
Not Yet Recruiting
Research Team
T
Toni T Seppälä, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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