Actively Recruiting
Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations
Led by RenJi Hospital · Updated on 2024-04-16
380
Participants Needed
3
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Delayed graft function (DGF), delineated by the necessity for dialytic intervention within the initial week post-transplantation, afflicts approximately 20%-50% of recipients. The primary objective of this study is to investigate the potential efficacy of norepinephrine infusion in conjunction with goal-directed fluid therapy (GDFT) in mitigating the occurrence of DGF among individuals undergoing kidney transplantations. The findings of this investigation have the potential to advance the field of perioperative care in kidney transplantations by providing insights into optimized management strategies.
CONDITIONS
Official Title
Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Recipients aged 18 years or older
- Scheduled to undergo kidney transplantations under general anesthesia
- Cadaveric kidney transplantations
- Signed informed consent form
You will not qualify if you...
- Donors aged under 18 years
- Donor kidneys classified as Maastricht category I or II
- Contraindications to radial artery catheterization
- Pregnancy
- Cardiac dysfunction with exercise tolerance less than 4 METS
- Severe liver dysfunction (Child Pugh C-grade)
- Respiratory diseases with tidal volume intolerance exceeding 8 ml/kg
- Severe arrhythmias including atrial fibrillation and frequent premature beats
- Double-kidney transplantations
- Simultaneous organ or additional surgeries during kidney transplantations
- Repeat kidney transplantations
- Concurrent participation in other clinical trials
- Patients deemed ineligible by researchers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
the First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Not Yet Recruiting
2
General Hospital of Northern Theatre Command
Shenyang, Liaoning, China, 110016
Not Yet Recruiting
3
Renji Hospital
Shanghai, Shanghai Municipality, China, 200127
Actively Recruiting
Research Team
D
Diansan Su, Dr.
CONTACT
M
Muyan Shi, B.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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