Actively Recruiting
Norepinephrine on Maternal Hypotension After Combined Lumbar and Epidural Anaesthesia
Led by The Third People's Hospital of Bengbu · Updated on 2024-07-12
100
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Norepinephrine has emerged as a potential alternative for stabilizing blood pressure during spinal anesthesia for cesarean section, purportedly maintaining maternal heart rate and cardiac output more effectively than phenylephrine. However, its application as an intravenous bolus for treating hypotension remains underexplored. Consequently, this current investigation aimed to determine the ED50 and ED95 of norepinephrine for managing maternal hypotension during cesarean section. A prospective trial enrolled 100 patients undergoing elective delivery under spinal anesthesia, with norepinephrine dosage determined using the upper and lower sequential distribution method (UDM).
CONDITIONS
Official Title
Norepinephrine on Maternal Hypotension After Combined Lumbar and Epidural Anaesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women undergoing elective cesarean section with combined lumbar and rigid anesthesia
- Healthy singleton pregnancies at full term (more than 37 weeks gestation)
- American Society of Anaesthesiologists physical status I or II
- Body weight between 50 and 100 kg
- Height between 150 and 180 cm
- Fasting for more than 8 hours
You will not qualify if you...
- Hypertension
- Cardiovascular diseases
- Preeclampsia
- Arrhythmias
- Diabetes mellitus
- Spinal cord malformations
- Abnormal fetal conditions
- Declined to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Third People's Hospital of Bengbu
Bengbu, Anhui, China, 233000
Actively Recruiting
Research Team
C
Chengfei Xu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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