Actively Recruiting

Phase Not Applicable
Age: 18Years - 39Years
All Genders
NCT06312696

Normalizing Cervical Intersegmental Kinematics With Spinal Manipulative Therapy

Led by University of Minnesota · Updated on 2026-04-06

60

Participants Needed

1

Research Sites

156 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The broad long-term objective is to develop an objective biomarker for spinal health based on aberrant or abnormal movement patterns during functional activities to better target spinal manipulation therapy (SMT) and other conservative treatments. The central hypotheses are a) that aberrant spinal motions and their location (area and level) are indicative of underlying spinal dysfunction, and b) that quantified 3D cervical spine intersegmental and global motion patterns during functional tasks can be used as a biomarker for subsequent clinical studies aimed at normalizing cervical kinematics. Specific Aim: Determine the extent to which SMT can modulate, or normalize, intersegmental motion in patients with neck pain. Rationale: SMT is a force-based biomechanical event whose hypothesized mechanism of action relies on moving the segment into the para-physiological zone, resulting in normalization of spinal kinematic function. Hypothesis: Severity of abnormal or aberrant motion, identified in those with NP, will improve following SMT. Approach: Participants with chronic mechanical neck pain will be recruited and randomized into one of three groups: 1) No Treatment, 2) Light Massage (pseudo- sham), and 3) Spinal Manipulative Therapy. Using a repeated measures study design, metrics of quality of spinal motion will be compared before and after the prescribed intervention.

CONDITIONS

Official Title

Normalizing Cervical Intersegmental Kinematics With Spinal Manipulative Therapy

Who Can Participate

Age: 18Years - 39Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 to 39 years
  • Chronic nonspecific mechanical neck pain equivalent to grades I or II for more than 12 weeks
  • Neck pain intensity greater than 3 on a 0-10 scale
Not Eligible

You will not qualify if you...

  • American Society of Anesthesiology Class III conditions or serious mental health conditions
  • Botox injections resulting in relief within the past 3 months
  • Chronic opioid use
  • Contraindications to spinal manipulation such as cervical instability or neurological complications
  • Spinal manipulation or mobilization of cervical spine within the past 6 months
  • Ongoing non-drug treatment for neck pain
  • History of cervical spine surgery
  • Pregnancy, attempting pregnancy, or lactation
  • Contraindications to radiation exposure

AI-Screening

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Trial Site Locations

Total: 1 location

1

University of Minnesota

Minneapolis, Minnesota, United States, 55414

Actively Recruiting

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Research Team

S

Stephany Nathe

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

3

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