Actively Recruiting
Normative Brain Volume Profiles From Multicenter Fetal MRI
Led by Assistance Publique Hopitaux De Marseille · Updated on 2025-06-11
1423
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Fetal brain MRI is an essential diagnostic tool to inform parents about the prognosis of abnormalities detected on routine ultrasound. Recent work has shown that brain MRI measurements at the antenatal stage are predictive of the child's postnatal development. However, this work remains limited to basic research, in part because of the lack of normative curves of brain tissue volume evolution from fetal MRI acquired in clinical routine. This project aims to fill this gap. For this purpose, the project will exploit fetal MRI scans acquired in 4 French hospitals (Marseille, Nice, Montpellier and Paris): MRI scans without abnormalities will be centralized for analysis, and families who have undergone these scans will be contacted to evaluate the development of their children after birth. Normative curves will be established by applying a set of treatments developed by the laboratory in Marseille collaborating in the project. Ultimately, these curves will help to clarify the diagnosis of fetuses by providing a quantitative characterization of the normality of brain measurements.
CONDITIONS
Official Title
Normative Brain Volume Profiles From Multicenter Fetal MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Child who had a cerebral MRI during the fetal period more than 3 years ago at one of the 4 partner centers
You will not qualify if you...
- Child with a commissural malformation (anomaly of the corpus callosum)
- Child with a genetic syndrome, chromosomal abnormality, or harmful mutation
- Child with syndromic extra-cerebral malformations, including cardiac malformations
- Child with intrauterine growth restriction reported in obstetrical records
- Child with confirmed maternal-fetal infection (TORCH, parvovirus, or others)
- Child from a multiple pregnancy
- Mother treated for diabetes during pregnancy, including gestational diabetes
- Mother treated with antiepileptic medication during pregnancy
- Alcohol or drug use during pregnancy
- Presence of a sustentorial arachnoid cyst
- Presence of an arachnoid cyst causing mass effect
- Parental authority holders object to participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU Timone
Marseille, France, 13005
Actively Recruiting
Research Team
N
Nadine Girard, Pr
CONTACT
A
Aurélie Ponz
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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