Normative Brain Volume Profiles From Multicenter Fetal MRI Scans to Assess Prenatal Development

What this Trial Is About

Researchers are studying fetal brain development by creating normal brain volume curves using MRI scans taken during pregnancy. These curves aim to help doctors better understand and diagnose abnormalities detected by routine ultrasound. The project collects brain MRI scans from four French hospitals and follows up with families to assess their children's development after birth. This observational study focuses on brain tissue volume evolution and aims to improve diagnosis through quantitative brain measurements. The study uses fetal MRIs without abnormalities collected at partner hospitals in Marseille, Nice, Montpellier, and Paris. Families of children who had these scans more than three years ago will be contacted to complete questionnaires about their children's development. The project applies specialized analysis methods developed by the laboratory to establish normative brain volume curves. There is no treatment or intervention beyond observational data collection and questionnaires. Participants will provide information through questionnaires evaluating child development after birth. Researchers will analyze the MRI scans and compare brain volume curves with existing literature to validate their findings. They will also study how different MRI scanners might affect the results. The primary outcome is to determine normative brain volume curves, with follow-up averaging three years. Participation involves data collection and follow-up questionnaires but no direct medical procedures or treatments.

Normative Brain Volume Profiles From Multicenter Fetal MRI