Actively Recruiting
Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
Led by Massachusetts General Hospital · Updated on 2025-11-03
200
Participants Needed
1
Research Sites
178 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.
CONDITIONS
Official Title
Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-80 years
- Listed for liver transplantation at MGH
- Calculated MELD-Na score <= 25
- Able to consent
You will not qualify if you...
- Status 1a
- Cardiac or pulmonary disease
- Prior liver transplant
- Requiring pressors at the time of liver offer
- MELD <15 and asymptomatic from liver disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Brigham
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
H
Heidi Yeh, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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