Actively Recruiting

Age: 18Years +
All Genders
NCT07476274

Nosocomial Pneumonia After Coronary Artery Bypass Grafting

Led by Tomsk National Research Medical Center of the Russian Academy of Sciences · Updated on 2026-03-23

80

Participants Needed

1

Research Sites

143 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Observational studies of patients with coronary artery bypass grafting, associated with an unfavorable cardiopulmonary prognosis for at least one year after surgery. This is Prospective, cohort, unblinded, observational comparable single center clinical trial. To compare the clinical, laboratory (including complete blood count, metabolic panel, and specific cardiac, inflammatory, infectious, and endothelial biomarkers), functional (ECG, echocardiography, ultrasound, spirometry, cardiopulmonary exercise testing), and radiological (chest X-ray/CT) phenotypes in patients with coronary artery bypass grafting with and without non-ventilator-associated postoperative, nosocomial pneumonia; to identify the factors of early and 1-years cardiopulmonary prognosis. Increased risk of cardiovascular outcomes is related with the circulatory arrest, artificial circulation, perioperative trauma and respiratory complications of the postoperative period associating to the different severity and duration of the systemic inflammatory response, immune status disorders, hemostasis disorder, endothelial dysfunction, external respiration dysfunction, anatomic and functional disorders in the heart and lungs. Individual predictors of an unfavorable prognosis can be determined at the stage of before and just after surgery to conduct personalized prevention. This study aimed to compare the clinical, laboratory (including complete blood count, metabolic panel, and specific cardiac, inflammatory, infectious, and endothelial biomarkers), functional (ECG, echocardiography, ultrasound, spirometry, cardiopulmonary exercise testing), and radiological (chest X-ray/CT) phenotypes in patients after coronary artery bypass grafting with and without non-ventilator-associated postoperative nosocomial pneumonia; to identify the factors of early and 1-years cardiopulmonary prognosis.

CONDITIONS

Official Title

Nosocomial Pneumonia After Coronary Artery Bypass Grafting

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years and older.
  • Myocardial revascularization for coronary artery disease via coronary artery bypass grafting during the current hospitalization following ESC/EACTS Guidelines.
  • Successful transfer from intensive care unit to general ward after surgery.
  • Presence of one or more risk factors for nosocomial pneumonia.
  • Signed informed consent to participate in the study.
Not Eligible

You will not qualify if you...

  • Acute coronary syndrome within the last 1 month.
  • Combined surgical intervention for infective endocarditis.
  • Combined valve surgery.
  • Pulmonary disease requiring respiratory support before surgery.
  • Presence of a tracheostomy.
  • Participation in another clinical trial currently or within the past 3 months.
  • Diagnosis of malignant tumors within the last 5 years.
  • Life expectancy less than 1 year.
  • HIV infection.
  • Ventilator-associated pneumonia.
  • Acute myocardial infarction after CABG and before inclusion.
  • Acute stroke after CABG and before inclusion.
  • Pulmonary complications including edema, ARDS, or pneumothorax requiring drainage after CABG and before inclusion.
  • Delirium after CABG and before inclusion.
  • Chronic kidney disease stage 4-5 or acute kidney injury requiring dialysis or renal replacement therapy.
  • Any perioperative complication requiring return to intensive care or ICU stay longer than 48 hours.
  • Any other active infection at a different site.
  • COVID-19 infection.

AI-Screening

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Trial Site Locations

Total: 1 location

1

Cardiology Research Institute of Tomsk NRMC

Tomsk, Tomsk Oblast, Russia, 634012

Actively Recruiting

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Research Team

R

Roman S. Timoshenko, MD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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