Actively Recruiting

Phase 1
Age: 18Years +
All Genders
NCT06312748

Novel Approaches for Improving Vascular Function in Veterans With HFpEF

Led by VA Office of Research and Development · Updated on 2026-04-23

90

Participants Needed

1

Research Sites

488 weeks

Total Duration

On this page

Sponsors

V

VA Office of Research and Development

Lead Sponsor

U

University of Utah

Collaborating Sponsor

AI-Summary

What this Trial Is About

This project will evaluate the impact of L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin administration on physical capacity and vascular function in Veterans with heart failure with preserved ejection fraction (HFpEF).

CONDITIONS

Official Title

Novel Approaches for Improving Vascular Function in Veterans With HFpEF

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older and able to give written informed consent.
  • New York Heart Association (NYHA) functional class I, II, or III.
  • Left Ventricular Ejection Fraction (LVEF) > 50%.
  • Plasma Brain Natriuretic Peptide (BNP) ≥ 150 pg/mL or NT-proBNP ≥ 600 pg/mL at Visit 1, or BNP ≥ 100 pg/mL (or NT-proBNP ≥ 400 pg/mL) and a hospitalization for heart failure within the last 12 months.
Not Eligible

You will not qualify if you...

  • History of hypersensitivity or allergy to any lipophilic statin.
  • Prior EF <50%.
  • NYHA Class IV.
  • Patients with HFpEF secondary to significant uncorrected primary valvular disease.
  • Active liver disease or unexplained persistent elevations in serum transaminase.
  • Women who are pregnant or may become pregnant.
  • Patients currently treated with antioxidants, nitrates, PDE-5 inhibitors, or statins.

AI-Screening

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Trial Site Locations

Total: 1 location

1

VA Salt Lake City Health Care System, Salt Lake City, UT

Salt Lake City, Utah, United States, 84148-0001

Actively Recruiting

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Research Team

D

David W Wray, PhD

CONTACT

M

Misti R Seppi, MBA BS AAS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

TREATMENT

Number of Arms

6

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