What is P3-EX studying for patients with cardiovascular disease risk factors?

P3-EX is being studied as a digital tool to help physicians personalize exercise prescriptions for patients with cardiovascular risk factors. The study evaluates how usable and acceptable this tool is for doctors and patients, and whether it can improve patients' physical activity and cardiovascular health. The University of Connecticut leads this research to address exercise prescription barriers in healthcare.

Who may be eligible for this cardiovascular disease clinical trial?

Adults aged 18 to 64 years with at least one cardiovascular risk factor such as obesity, hypertension, dyslipidemia, or diabetes may be eligible. Participants must be sedentary and able to use a computer or phone with internet access. This trial includes all genders and excludes those who are pregnant, smokers, or have health conditions limiting physical activity. Please review eligibility criteria for more details.

Is there any cost to participate in this cardiovascular disease clinical trial?

Study-related care, including the study exercise programs and all trial visits, is provided at no cost. Personal expenses such as travel may vary and are not guaranteed to be covered. Participants should plan accordingly for any additional costs related to attending visits or following the study procedures.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 64Years

All Genders

ID07238556

Feasibility and Acceptability of a Novel Algorithm for Physicians to Prescribe Personalized Exercise to Patients With Cardiovascular Disease Risk Factors

Led by University of Connecticut · Updated on 2026-04-15

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are evaluating a new digital health tool called Prioritize Personalize Prescribe EXercise P3-EX designed to help physicians prescribe personalized exercise plans to adults with cardiovascular disease CVD risk factors such as obesity, hypertension, dyslipidemia, and diabetes. This pilot randomized controlled trial aims to test the usability and satisfaction of P3-EX compared to a standard exercise prescription method ACSM Physical Activity Vital Sign among physicians and their patients. The study addresses barriers physicians face in prescribing exercise, including lack of time, training, and tools. Physicians recruited for the study will each recruit two patients with CVD risk factors. One patient receives a personalized exercise prescription using P3-EX, and the other receives a generic exercise program based on ACSM guidelines, delivered in a random crossover design. Patients will follow their assigned exercise plans unsupervised for 12 weeks with virtual weekly support from graduate research assistants. The P3-EX tool assesses cardiovascular risk factors, prioritizes the greatest risk, and creates a tailored Frequency, Intensity, Time, and Type FITT exercise prescription. Patients will record their exercise activities in a diary and receive weekly progress reports and guidance. Participants will attend several in-person visits for assessments including cardiovascular risk factors, physical activity levels measured by accelerometry, and blood tests. Physicians and patients will rate the feasibility and acceptability of each prescription method shortly after delivery. Patient exercise adherence and changes in cardiovascular health and physical activity will be monitored over 12 weeks. The study includes virtual visits for guidance and ends with follow-up assessments to evaluate patient satisfaction and health outcomes. The total participation time for patients covers baseline and post-intervention visits plus the 12-week exercise period.

CONDITIONS

Brief Title

A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors

Who Can Participate

Age: 18Years - 64Years

All Genders

Eligibility Criteria

You may qualify if you...

Physicians who are practicing medical doctors at the study sites
Physicians who do not currently recommend written exercise plans or refer patients to exercise professionals
Physicians willing to recruit two patients for both P3-EX and ACSM-PAVS exercise prescriptions
Patients aged 18 to 64 years
Patients sedentary, not performing moderate structured exercise at least 30 minutes on 3 or more days per week in the last 3 months
Patients with at least one cardiovascular risk factor: obesity, hypertension, dyslipidemia, or diabetes (including prediabetes)
Patients classified as healthy without signs or symptoms of cardiovascular, renal, or other diseases limiting physical activity
Patients not pregnant or lactating
Patients who do not smoke or quit smoking at least 6 months ago
Patients consuming fewer than 2 alcoholic drinks daily
Patients able to use a computer or phone with internet access
Patients fluent in English
Patients willing to maintain current medication routines and diet, and not follow other exercise or nutrition programs

You will not qualify if you...

Patients experiencing chest, neck, jaw, or arm pain; dizziness; shortness of breath at rest or mild exertion; unusual fatigue; swelling; palpitations; or known heart murmur
Patients who are stroke or cancer survivors, currently have cancer, chronic obstructive pulmonary disease, musculoskeletal injuries, chronic back pain, depression, dementia, or other health conditions limiting physical activity engagement

Research Team

Alexander J Wright, MS

Linda S Pescatello, PhD

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