Actively Recruiting
A Novel Ferumoxytol-enhanced Cardiac Magnetic Resonance for the Detection of Calcified Coronary Arteries
Led by The First Affiliated Hospital with Nanjing Medical University · Updated on 2026-02-10
100
Participants Needed
1
Research Sites
187 weeks
Total Duration
On this page
Sponsors
T
The First Affiliated Hospital with Nanjing Medical University
Lead Sponsor
C
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is a single-center, prospective, controlled, diagnostic study. The study will be consecutive and is expected to enroll 100 patients with CCTA confirmed coronary calcified lesions. The purpose of this study was to compare the accuracy of novel Ferumoxytol-enhanced Cardiac Magnetic Resonance (Fe-CMR) and coronary CT angiography (CCTA) in detecting calcified coronary arteries, using coronary angiography (CAG) and optical coherence imaging (OCT) as gold standards.
CONDITIONS
Official Title
A Novel Ferumoxytol-enhanced Cardiac Magnetic Resonance for the Detection of Calcified Coronary Arteries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older and younger than 75 years
- Coronary CT angiography images taken within 30 days showing calcification occupying more than 50% of the vascular lumen in major coronary artery segments
- Planned to undergo coronary angiography
- Normal kidney function or chronic kidney disease stage 1 to 3
- Signed informed consent
You will not qualify if you...
- Allergy to iodine contrast media, iron, or dextran
- Unable to undergo MRI due to psychological reasons (such as claustrophobia) or physical reasons (such as metal implants)
- Terminal illness or life expectancy less than 1 year
- Pregnant or breastfeeding women
- Hearing impairment
- Severe heart failure (grade III-IV)
- History of coronary artery stent placement or bypass surgery
- Currently using other iron-containing medications
- Diagnosis of hemosiderosis or hemochromatosis
- Acute coronary syndrome
- Hyperthyroidism
- Any other conditions deemed unsuitable by researchers
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China, 210000
Actively Recruiting
Research Team
C
Chunjian Li, Phd、MD
CONTACT
Q
Qin Wang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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