Actively Recruiting
Novel Ga68-PSMA PET/CT-tracer to Differentiate Between Radiation Necrosis and Tumor Progression in Brain Metastases
Led by The Netherlands Cancer Institute · Updated on 2026-04-06
100
Participants Needed
1
Research Sites
392 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to evaluate the diagnostic potential of 68-Gallium PSMA-PET/CT in stereotactic irradiated brain metastases from non-small cell lung cancer, melanoma and breast cancer.
CONDITIONS
Official Title
Novel Ga68-PSMA PET/CT-tracer to Differentiate Between Radiation Necrosis and Tumor Progression in Brain Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- Age 18 years or older
- WHO Performance Status 0 to 3
- Measurable brain lesion 10 mm or larger
- Newly diagnosed brain metastases from non-small cell lung cancer, melanoma, or breast cancer
- For radiation necrosis groups: brain lesion at location of formerly treated brain metastases with diagnosis of radiation necrosis more than 9 months after stereotactic radiotherapy
- For diagnostic dilemma groups: brain lesion at location of formerly treated brain metastases with diagnostic uncertainty between radiation necrosis and tumor recurrence
You will not qualify if you...
- Known allergy to Gallium-68 PSMA
- Epileptic seizure less than 7 days before PET/CT scan
- Life expectancy less than 3 months
- Known prostate carcinoma
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Netherlands Cancer Institute - Antoni van Leeuwenhoek
Amsterdam, Netherlands, 1066 CX Amsterdam
Actively Recruiting
Research Team
L
Lente Kroon, MD
CONTACT
D
Dieta Brandsma, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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