Actively Recruiting
A Novel Individualized Connectome-guided Approach for Precision Intermittent Theta Burst Stimulation for Depression
Led by Institute of Mental Health, Singapore · Updated on 2024-08-01
70
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
Sponsors
I
Institute of Mental Health, Singapore
Lead Sponsor
N
National University of Singapore
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Investigators propose to carry out a randomized, double-blind trial to compare the clinical efficacy of an individualized connectome-guided accelerated iTBS vs an anatomically-guided (Beam F3) accelerated iTBS. The study team will recruit both inpatients and outpatients who had been referred for TMS for the treatment of depression.
CONDITIONS
Official Title
A Novel Individualized Connectome-guided Approach for Precision Intermittent Theta Burst Stimulation for Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21 years or older
- Diagnosis of current Major Depressive Episode by DSM-5
- Montgomery-Asberg Depression Rating Scale score of 20 or more
- Inadequate response after at least 4 weeks of antidepressant medication
- Able to give informed consent
You will not qualify if you...
- Diagnosis of a DSM-5 psychotic disorder
- Drug or alcohol abuse or dependence within the past 3 months
- Requirement for rapid clinical response such as high suicide risk
- Significant neurological disorders posing increased risk with TMS, such as epilepsy
- Presence of metal in the cranium, skull defects, pacemaker, cochlear implant, medication pump, or other electronic device
- Pregnancy
- Unsuitable for MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institute of Mental Health
Singapore, Singapore, 539747
Actively Recruiting
Research Team
P
Phern Chern Tor, MBBS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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