Completed

Phase Not Applicable
Age: 18Years - 99Years
All Genders
ID05643027

A Novel Intervention for Avoidance-Related Opioid Misuse in Patients With Cancer

Led by Dana-Farber Cancer Institute · Updated on 2026-05-14

40

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

D

Dana-Farber Cancer Institute

Lead Sponsor

N

National Cancer Institute (NCI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research study is being done to develop an intervention for psychological symptoms that patients diagnosed with cancer may experience. Psychological symptoms may include thoughts, feelings, emotions, and memories The names of the study intervention and research activities involved in this study are/is: * Acceptance \& Commitment Therapy (ACT) for Cancer (involving 6 sessions with a licensed clinical psychologist) * Questionnaires * Post-study interview Consistent with the NIH Stage Model for Behavioral Intervention Development, the investigators have adapted an existing, empirically-validated intervention, Acceptance and Commitment Therapy (ACT), to address substance use disorder risk during cancer care. The core components of ACT are particularly well-suited to address the psychological processes underlying opioid misuse in individuals treated for cancer pain. The overarching aim is to assess the feasibility and acceptability of the intervention by conducting a randomized pilot trial of the revised intervention ("ACTION") for cancer patients on opioid therapy, and at risk for SUD.

CONDITIONS

Official Title

A Novel Intervention for Patients With Cancer

Who Can Participate

Age: 18Years - 99Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • at least 18 years old
  • have an estimated survival time of at least 6 months (as estimated by palliative care provider)
  • score at least 4 on the Opioid Risk Tool (ORT)
  • have been diagnosed with any cancer, including hematologic malignancies
  • performance status criterion of 0, 1, or 2 [ with 0 indicating that the patient is asymptomatic, 1 that the patient is symptomatic but fully ambulatory, and 2 that the patient is symptomatic and in bed <50% of the day]
Not Eligible

You will not qualify if you...

  • Patients with a score at least 3 to ensure that all enrolled patients are able to participate in the intervention, complete assessments, ensure that no patients who are too sick to participate are enrolled; this will enhance the rigor of the study)
  • currently be on opioid therapy
  • not meet criteria for current substance use disorder
  • assessed by the Diagnostic & Statistical Manual of mental disorders; DSM-5 or be receiving substance use disorder treatment; and speak and comprehend English sufficiently to be able to participate in psychotherapy.

Trial Site Locations

Total: 1 location

1

Dana Farber Cancer Institute

Boston, Massachusetts, United States, 02215

Status Unknown

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How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

1

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Published Research Related To This Trial

Study protocol for a pilot randomised controlled trial of a virtually delivered behavioural intervention (ACTION) for adults with cancer at risk for opioid use disorder.

Miryam Yusufov, William F Pirl, Joseph A Greer...

https://pubmed.ncbi.nlm.nih.gov/39638585
A Novel Intervention for Avoidance-Related Opioid Misuse in Patients With Cancer | DecenTrialz