Actively Recruiting
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
Led by Englewood Hospital and Medical Center · Updated on 2025-07-23
125
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how the body produces carbon monoxide (CO) after part of the liver has been surgically removed. The study focuses on measuring CO levels in breath as a way to understand how well the liver regenerates and to predict possible liver-related complications after surgery. This research aims to better monitor liver healing and assess liver function following surgery. All participants will provide breath samples to measure carbon monoxide levels before surgery, then again 4 hours and 24 hours after liver resection. The study will track these CO levels alongside the amount and quality of liver regeneration over time. Liver volume and function will be assessed at one and three months after the surgery to correlate with the CO measurements. Participants will be monitored through breath tests and follow-up visits to measure liver regeneration and function. Researchers will collect data on CO levels in exhaled air and compare them to liver volume and function results. The main outcome is to find a link between CO levels and liver healing, which may help predict liver-related health issues after surgery. The study is expected to continue until 2039.
CONDITIONS
Brief Title
Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient plans to have partial liver resection for primary liver pathology or metastatic disease
- Patient is able to comprehend and willing to sign the written consent form
You will not qualify if you...
- Patients under 18 years of age
- Patients identified as members of a vulnerable population, except women of childbearing potential with negative pregnancy test
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo partial liver resection and provide breath samples for carbon monoxide measurements before surgery, and at 4 hours and 24 hours after surgery.
1 day with 3 breath sample measurements
Duration - 3 months
Participants have assessments of liver regeneration quantity and quality through liver volume and function measurements at one month and three months after surgery.
2 visits (at 1 month and 3 months post-resection)
Trial Site Locations
Total: 1 location
1
Englewood Hospital
Englewood, New Jersey, United States, 07631
Actively Recruiting
Research Team
J
Jamie Ketas
R
Raquel Molina
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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