Actively Recruiting
A Novel Molecular Approach to Blood DNA Screening for Cancer: Specificity Assessment (The NOMAD Study)
Led by Mayo Clinic · Updated on 2026-03-10
10000
Participants Needed
1
Research Sites
1052 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is being done to establish "normal' values for a new blood test and urine test approach to cancer screening. Patients undergo blood and urine sample collection on study. Patients' medical records are reviewed.
CONDITIONS
Official Title
A Novel Molecular Approach to Blood DNA Screening for Cancer: Specificity Assessment (The NOMAD Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients without a known internal (non-cutaneous) cancer or history of internal cancer
- Age 18 years or older, with recruitment balanced across age groups: 18-39, 40-49, 50-59, 60-69, 70-79, and 80 or older
- Roughly half of participants in each age group will be women
- Roughly half of participants will have had a negative colonoscopy or colon x-ray within the past 5 years, or Cologuard test within 3 years
- Roughly half of participants will have had a negative chest x-ray within the past 5 years
- Roughly half of women participants will have had a negative mammography in the past 5 years
- Subgroups recruitment goals include men with normal PSA levels (at least 200), patients with diabetes mellitus (at least 200), connective tissue diseases (at least 100), chronic obstructive lung disease (at least 100), inflammatory bowel disease or cirrhosis (at least 100), and pancreatitis (at least 100)
- Data collected on all participants will include BMI, smoking status, alcohol use, pregnancy status (for women), and selected medications including anti-inflammatory drugs, statins, anti-hypertensives, and anti-depressants
You will not qualify if you...
- Patients with current or past diagnosis of invasive cancer (excluding basal or squamous cell skin cancers)
- Patients who have had a solid organ transplant
- Inability to provide informed consent
- For urine sample collection: recent transurethral instrumentation (within 7 days), chronic indwelling urinary catheter, or urinary tract infection within 14 days prior
- For saliva sample collection: clinically significant dry mouth (xerostomia), recent active upper respiratory or anogenital infection within 30 days prior
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
E
Ellie Omerdic
CONTACT
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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