Actively Recruiting
A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections
Led by Ann & Robert H Lurie Children's Hospital of Chicago · Updated on 2025-01-15
35
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with recurrent UTI were randomized to receive either the probiotic Sacchromyces Boulardii at enrollment, and the intracellularly active Ciprofloxacin with their first UTI episode after enrollment, or they received standard of care treatment.
CONDITIONS
Official Title
A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of 3 or more UTI episodes in the past 12 months, or 2 or more episodes in the past 6 months
- No evidence of vesicoureteral reflux or only low-grade (grade 1-2) vesicoureteral reflux
- No other genitourinary anatomical abnormalities
- Not receiving prophylactic antibiotics at enrollment
- Ages 2 to 17 years
You will not qualify if you...
- High-grade (grade 3-5) vesicoureteral reflux
- Neurogenic bladder
- Anatomical abnormalities of the gastrointestinal tract
- History of urologic or gastrointestinal surgery
- Currently on prophylactic antibiotics
- Positive urine culture for pathogens resistant to ciprofloxacin in the last 3 months
- Allergic reaction or severe adverse reaction to ciprofloxacin or other quinolones
- Known history of myasthenia gravis
- Taking tizanidine or other drugs that interact with ciprofloxacin
- Known QT prolongation, hypokalemia, or taking drugs that prolong QT interval
- Younger than 2 years old
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Lurie Children's Hospital
Chicago, Illinois, United States, 60611
Actively Recruiting
Research Team
M
Mehreen Arshad, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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