A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections

Led by Ann & Robert H Lurie Children's Hospital of Chicago · Updated on 2026-07-01

Participants Needed

Research Sites

52 weeks

Total Duration

AI-Summary

What this Trial Is About

Patients with recurrent UTI were randomized to receive either the probiotic Sacchromyces Boulardii at enrollment, and the intracellularly active Ciprofloxacin with their first UTI episode after enrollment, or they received standard of care treatment.

CONDITIONS

Brief Title

A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections

Who Can Participate

Age: 2Years - 17Years

All Genders

Healthy Volunteers

Eligibility Criteria

Inclusion Criteria:

A history of 3 or more UTI episodes in the past 12 months, or 2 or more episodes in the past 6 months
no evidence of vesicoureteral reflux or only low-grade (grade 1-2) vesicoureteral reflux
no other genitourinary anatomical abnormality
not receiving prophylactic antibiotics at the time of enrollment
Ages 2-17 years.

Exclusion Criteria:

high grade (grade 3-5) vesicoureteral reflux
neurogenic bladder
anatomical abnormalities of the gastrointestinal tract
any history of urologic or gastrointestinal surgery
on prophylactic antibiotics
a urine culture positive for pathogens that are not susceptible to ciprofloxacin in the last 3 months
history of an allergic reaction to ciprofloxacin or other quinolones, or a history of severe adverse reactions
As stated on the package insert for Ciprofloxacin, individuals with a known history of myasthenia gravis should avoid taking Ciprofloxacin and therefore will be excluded from this study.
Based on the black box warning for Ciprofloxacin, individuals taking tizanidine as concomitant administration, or those taking other drugs known to interact with ciprofloxacin will be excluded from the study.
individuals with known QT prolongation, hypokalemia, or on other drugs that prolong the QT interval should also avoid taking Ciprofloxacin and will be excluded from this study.
Individuals under 2 years old. In the BFIT clinic, because they do bladder, bowel movement, and constipation management, it is harder to manage if the patient is not potty trained. Therefore, we are excluding participants under 2 years of age.

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A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria